Long-term follow-up of vagus nerve stimulation in drug-resistant KCNT1-related epilepsy: a case presentation
Wang, M., Geng, G., Meng, Y. et al.
Acta Epileptologica 4, 34 (2022).
https://doi.org/10.1186/s42494-022-00105-0
#KCNT1-related #epilepsy is a very rare, infant-onset #seizure disorder caused by KCNT1 gene mutations. It can cause severe, intractable seizures and encephalopathy. This case report by Wang et al. (2022) describes a 9-year-old, nonverbal boy with KCNT1-related epilepsy whose seizures were significantly controlled by vagus nerve stimulation (#VNS) treatment.
The boy had drug-resistant epilepsy (#DRE) with focal seizures since age 3. He had multiple seizure types that only occurred during the night, with automatisms as the most common seizure type. Other diagnoses included epileptic encephalopathy and cognitive disorder. He underwent VNS implantation at age 7 after the trial of multiple antiseizure medications (#ASMs) and ketogenic diet therapy.
Seizure frequency was significantly decreased after 3 months of VNS treatment, using the following parameter settings: 1.6 mA, 30 Hz, 250 μs, 30 s on time, and 5 min off time. Other improvements could be observed in background electroencephalography (EEG) and mood.
To gain more knowledge about KCNT1-related epilepsy, VNS Therapy, and our company, check out the websites:
KCNT1 Epilepsy Foundation: https://kcnt1epilepsy.org/
VNS Therapy: https://lnkd.in/ejjZ3RD4
Go North Medical: https://lnkd.in/eUKuEfbM
Link to the article: https://lnkd.in/gPDf5bZk
